The barnidipine hydrochloride were prepared via cyclocondensation from m-nitrobenzaldehyde, methyl acetoacetate and anmmonium bicarbonate, hydrolysis, esterification with opticaliy (S)-N-Benzyl-3-py-rrolidinol, recrystallisation and salification.

• 摘要研究了以碳酸氢铵，间硝基苯甲醛和乙酰乙酸甲酯为原料，经缩合、部分水解，再与(s)-N-苄基－3-羟基吡咯烷经酯化、分步重结晶、成盐得到盐酸巴尼地平的工艺路线。