The antisense peptides of the C5a could inhibit the C5a anaphylatoxin function that induced ICAM 1 expression, and could decrease the MPO activity of the adhesion PMN cell.

• 髓过氧化物酶 (myeloperoxi dase ；MPO)为单核细胞PMN所特有 ；其活性可以间接反映C5a趋化白细胞的能力 ；C5a刺激血管内皮细胞表达胞间粘附分子 (ICAM 1)、血管间粘附分子 (PCAM 1)等 ；后者能增加对PMN的粘附 ；检测MPO活性可间接反映出C5a的功能 .