The activity of p-ERK1/2 can regulate the expression of P27 and both of them may play an important role in the genesis and development of human gastric carcinoma.

• p-ERK1/2可通过抑制P27蛋白的表达,促进基质溶解、增加胃癌细胞的侵袭力,从而在胃癌的浸润、转移中起到重要的作用。