The accumulation of cholesterol (in the form of the macrophage foam cell) within lesions is presumably due to insufficient activity of key lipid efflux, catabolic pathways, or both.

• 在病损局部胆固醇的累积（以巨噬细胞源性的泡沫细胞形成的形式）被假定分别由关键脂质排出、催化机制的活性下降导致或者二者皆共同参与所导致。