The Neotame was synthesized from isobutylene, ethylene and Aspartame via addition, oxidation, catalytical hydrogenation in 14.5% total yield, the physical properties and Infrared Spectroscopy of product are identical with literature.

• 摘要以异丁烯、乙烯和阿斯巴甜为原料，经加成、氧化和催化氢化等步骤合成了纽甜，总产率14.；5%25（以异丁烯计），产品的物理性质与波谱数据与文献一致。