The HRT of the association between progestogen and estrogen grows downwards the risk , but the onset risk of breast cancer, cardiovascular and cerebrovascular disease increase.

• 与孕激素联合应用的激素替代疗法，虽然能减少这种风险，但乳腺癌及心脑血管病的发病风险增加，雌激素在临床长期应用所带来的不良反应一直困扰着人们。