Rimantadine hydrochloride was synthesized from adamantane via bromination, acetylation and addition with formamide followed by hydrolysis. The overall yield was 31.5%.

• 以金刚烷为起始原料 ；经溴化、乙酰化、甲酰胺加成和水解反应 ；制得盐酸金刚乙胺 ；总收率 31.；5%25。