Results The expression of NR1 mRNA and protein in DMEM medium had higher value level at culture day in vitro (DIV) 7,and then they decreased gradually and had the lowest value at DIV12.They increased again with development.

• 与CONT2和CONT1组相比；MGF组NR1mRNA与蛋白的表达在培养7d皮层神经元均明显降低；在12d时明显增高(P<0.；05)。