Renal proximal tubule sodium reabsorption were inhibited and sodium excretion incresed after administration of losartan independently of an alteration in glomerular filtration rate.

• 在GFR不改变的情况下，小剂量的氯沙坦在对照组和哇巴因组均可引起近端小管钠重吸收与钠排泄显著增加，但在哇巴因组的利钠效应明显强于对照组。