Purpose: A clinical study was performed to determine the safety and efficacy of temozolomide(TMZ) vs. semustine (CCNU) in patients with malignant gliomas.

• 目的：应用替莫唑胺(TMZ)以司莫司丁(CCNU)作为对照研究两者对恶性脑胶质瘤化疗的安全性和有效性。