Phylogenetic analysis showed that the ELR motif in mammalian may be typical evolved for chemotactic special cell from the ancient IL8.It is absent in lamprey and only has substitution in piscine IL-8.

• 而哺乳类的ELR结构可能为IL-8在进化过程中特化而成的结构,以加强IL-8特异性的趋化能力。