Our research is helpful to understand the state of SPG in China and provide useful clue not only to clone gene of SPG but also to identify pathways for pathogenesis of HSP.

• 这些结果不仅为进一步摸清我国本病的致病基因种类及突变类型，也为进一步克隆SPG基因提供了非常重要的线索和条件，同时也朝着找寻本病的预防及治疗途径向前迈进了一步。