Objective To study the effect of hypoxia on breast cancer cell MCF7 invasion through Matrigel and the expression of MMP-2, u-PAR, FN mRNA level in vitro.

• 目的研究体外缺氧对乳腺癌细胞系MCF7浸润能力及其细胞表面金属蛋白酶MMP-2、丝氨酸蛋白酶u-PA受体u-PAR和细胞基质蛋白FN的表达的影响。