Objective To investigate the roles of cyclin D1/CDK4-E2F-1/4 pathway in cell cycle changes of human embryo lung fibroblasts(HELF) induced by two different benzo(a)pyrene treatment models.

• 目的探讨细胞周期蛋白D1(cyclin D1)/细胞周期蛋白依赖激酶4(CDK4)-E2F-1/4通路在苯并(a)芘[B(a)P]引起的人胚肺成纤维细胞(HELF)周期改变中的作用。