Objective To investigate the effect of bufalin combined with all-trans retinoic acid-induced (ATRA) proliferation inhibition and differentiation and of acute promyelocytic leukemia (APL) cells NB4 in culture.

• 目的:研究蟾蜍灵与全反式维甲酸(ATRA)联合对急性早幼粒细胞白血病(APL)细胞株NB4 细胞的增殖抑制及诱导分化作用。 方法:细胞增殖及凋亡检测:将NB4细胞浓度调整至5×105个/ml, 接种于24孔培养皿中,每孔1ml。