Objective To investigate the augmentation effect and mechanism of all trans retinoic acid(ATRA)on the bystander effect of herpes simplex virus thymidine kinase (HSV TK)/ganciclovir(GCV) system in the treatment of tongue carcinoma cell line.

• 目的 探讨全反式维甲酸 (all transretinoicacid ,ATRA)对单纯疱疹病毒胸苷酸激酶(herpessimplexvirusthymidinekinase ,HSV TK) /丙氧鸟苷 (ganciclovir,GCV)系统治疗舌鳞癌旁观者效应的增强作用及机制。