Objective To explore the influence of combined immunization with the synthetic oligonucleotide containing CpG motif(CpG ODN) and rHBsAg on the histological change and lymphocyte proliferation of murine spleen.

• 目的探讨合成含CpG基序的寡核苷酸(CpGODN)与重组乙型肝炎表面抗原(rHBsAg)联合免疫对小鼠脾脏淋巴组织及细胞增殖的影响。