Obesity objects were more readily developing endothelium dysfunction in a way of increasing inflammatory factors (ICAM-1 included), and weight loss might convert this pathophysiological state10.

• 肥胖患者同时可通过分泌炎症因子（包括ICAM-1）导致血管内皮功能紊乱，减轻体重可纠正这一病理状态10。