OGD induced the reduction of GluR2 at postsynaptic membrane and the formation of GluR2 lacking AMPA receptors,which mediated the influx of Ca 2+ and resulted the delayed neuron death.

• 缺氧损伤可致突触后膜表面GluR2含量降低 ,形成缺乏GluR2的新的AMPA受体通道 ,介导了Ca2 + 的快速内流 ,引起神经元的延迟性死亡