OBJECTIVE To set up a population pharmacokinetic(PPK) model of Valproate(VPA) in children with epilepsy in China,and promote reasonable use of antiepileptic drugs(AEDs)in clinical practice.

• 目的建立中国癫痫儿童丙戊酸钠(VPA)的群体药动学(PPK)模型,促进个体化用药。