No serious bleeding ang fetal malformation.Conclusion: The right application program of anticoagulant drugs and perinal therapy is crytical to pregnancy women with prosthetic heart vavle replacement.

• 结论：在妊娠期间合理调整抗凝治疗方案，正确的围妊娠期处理是保证心脏机械瓣膜替换术后妊娠妇女安全度过危险期的关键。