No TSHR protein was found in the healthy subjects. Conclusion High TSHR expression in the EOM of TAO patients indicates that as a common antigen b etween the orbit and thyroid, TSHR play a key role in the patho-genesis of TAO.

• 结论TSHR蛋白TAO患者眼外肌组织中有表达,而在正常个体中没有表达,证实TAO患者球后眼外肌组织中存在有活性的TSHR蛋白,提示TSHR可能作为交叉抗原在TAO发病机制中起重要作用。