Myocyte apoptosis may play a pivotal role in MI,the suppression of Bcl-2 and the over expression of Bax,P53,Fas induce signal pathways of cardiomyocyte apoptosis, ACEI inhibits the cardiomyocyte apoptosis by effects of these genes.

• 大鼠急性心肌梗死后心肌细胞存在凋亡现象,Bcl-2表达下降,Bax、P53、Fas表达上调介导心肌梗死后心肌细胞凋亡的发生。 ACEI可通过干预上述基因抑制急性心肌梗死后的心肌细胞凋亡。