Mutation in the Livin BIR domain greatly enhances its instability and nullifies its binding to Smac/DIABLO, resulting in a reduced anti-apoptosis inhibition, while RING deletion mutant can still interact with Smac/DIABLO.

• 我们的研究赋予Livin一个新的重要的功能：Livin可以通过泛素-蛋白酶体途径来发挥E3泛素连接酶的功能促进促凋亡因子Smac/DIABLO的泛素化降解，从而在鬼臼乙叉甙诱导的细胞凋亡中更好的发挥其抑凋亡的功能。