Microbubbles destroyed by ultrasound with a frequency of 43 kHz and intensity of 1.2W/cm2 could induce BBB opening in rats, with minimal damage to brain tissue.

• 采用频率43kHz、声强1.；2W/cm2的超声波破坏微泡造影剂，可以使血脑屏障开放，同时对脑组织的损伤最轻。