MethodsThe content of sulfate groups was determined by converting heparin sodium into heparinic acid with cation exchange resin and by titrating with sodium hydroxide.

• 方法将肝素钠通过阳离子交换树脂转变为肝素酸,用氢氧化钠进行滴定,通过电导率的变化确定滴定终点,对硫酸基进行定量分析。