Methods:Path A:Formestane was synthesized by oxidation of androst 4 ene 3,17 dione with OsO 4/H 2O 2 followed by dehydration in KOH/MeOH medium.

• 方法:A.；以雄甾-4-烯-3；17-二酮(2)为原料；在极少量四氧化锇和30%25过氧化氢体系中将(2)氧化成4；5-二羟基-雄甾-3；17-二酮(3)。