Methods: SD rats were exposed to single or repeated WRS 4 h every other day for up to 6 days, the extent of gastric mucosal lesions were evaluated grossly and histologically.

• 方法：采用重复浸水束缚应激（WRS）制作动物模型，大体及光镜下动态观察粘膜损伤程度及组织学的变化。