Methods: Animal models of allergic rhinitis were created in eight guinea pigs by nasal drip of a sensitizing solution containing 10% Toluene 2, 4-diisocyanate in olive oil.

• 方法：用橄榄油将甲苯-2，4-二异氰酸酯配成浓度为10%25溶液作为致敏剂滴鼻，建立豚鼠变应性鼻炎动物模型8例。