Methods Drug permeability through excised full skin of rats was determined by using side-by-side diffusion cells device, and plasticizer (triethyl citrate) or permeation enhancers as solvents.

• 方法采用双室水平扩散池，大鼠腹部全皮为渗透膜，分别以增塑剂柠檬酸三乙酯或经皮穿透促进剂为溶剂，测定药物的体外经皮透过性。