Members in this pathway include the Janus kinases (JAKs) family containing JAK1, JAK2, JAK3 and TYK2 and the STATs (signal transducer and activator of transcription), which contain STAT1 to STAT6.

• 然而它所影响范畴包括了细胞增生、细胞命运的决定、组织的发育以及免疫系统反应。哺乳类动物中，JAK家族有JAK1, JAK2, JAK3 和TYK2，STAT家族则有STAT1-6。