Measuring the AUC over 24 h is probably preferable because of circadian variatio in physiologic functio and because of po ible variatio in dosing intervals and a orption rates during a day.

• 由于生理功能的昼夜变化，由于一天内给药间隔和吸收速率也可能发生变化，因此，24小时测一次AUC可能是最好的。