Many methods were investigated for the synthesis of the single enantiomer of the chiral intermediate, including chemical resolution, chemical asymmetric synthesis and chemo-enzymatic synthesis.

• 研究人员采用多种方法合成单一构型的地尔硫卓手性中间体，其中包括化学拆分、化学不对称合成以及化学-酶法合成等方法。