METHODS: Aromatic aldehyde and 3 equivalents of ammonium acetate were refluxed in methanol for 10 min to form Shiff base.Malonic acid was added and reaction mixture refluxed intensely for 16 h.

• 方法:以甲醇为反应溶剂,芳香醛和3当量醋酸铵反应生成希夫碱,再加入丙二酸,反应混合物剧烈回流16h得目标产物。