LP-CD4+OX40+T cells are a subset of autoreactive T cells stimulated by specific antigen in situ. Anti-OX40L MoAb can inhibit the proliferation response of this T cells.

• 结论:OX40在UC患者病变部位的LP-CD4+T细胞上表达明显增加,LP-CD4+OX40+T细胞是一类在原位被特异性抗原激活后扩增的T细胞,它们在UC的免疫病理机制中起重要作用。