Keywords Tuizhang gel;Tuizhang oculentum;orthogonal design;CCD-RSM;dissolution;quality standard;HPLC;irritating experiment;stability;

• 退障凝胶;退障眼膏;正交设计;星点设计-效应面优化法;释放度;眼部刺激性;稳定性;高效液相色谱法;