It was proposed by Marchuk in 1980.It is presented in the language of humoral immune reaction.The model was intensively studied by many people (see e.g. [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]).

• 很多人已经对这个模型作过深入的研究（见参考文献[2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]）。