It has been proposed that extra centrosomes generate CIN by promoting multipolar anaphase, a highly abnormal division that produces three or more aneuploid daughter cells.

• 人们长期所持的一个观点是，额外的中心体（它们与CIN有关联性）通过诱导混乱的多极纺锤体组装和非对称的细胞分裂来促使染色体错误分离。