In view of the important roles of SPARC in a variety of fibrotic diseases, this paper presents the relationship of SPARC to systemic sclerosis, wound healing and pathological scar and its mechanisms.

• 鉴于富含半胱氨酸的酸性分泌糖蛋白在多种纤维化疾病中的重要作用，概述其与系统性硬化病、创伤愈合及病理性瘢痕之间的关系及作用机制。