In pathological conditions, if RGS is out of control, their function of regulating G-protein pathway may be abnormal, thereby change the G protein signal transduction and do harm to tissue.

• 如果RGS出现异常，对G蛋白信号转导的调节就可能出现异常，从而引起G蛋白信号转导的改变而造成组织损害。