In order to get more structural information for designing new COX-2 inhibitors, COX-2 inhibitors that had been tested for the activity and selectivity were chosen to build two CoMFA model, using CoMFA (comparative molecular field analysis) method.

• 为得到更多的设计思路，利用已测定活性和选择性的三环系COX-2抑制剂分别建立结构与活性和结构与选择性两个CoMFA模型。