In free-carboplatin group 2 rabbits had abdomen metastasis and no lung metastasis. In microspheres group tumor were limited to liver and no metastasis.

• 兔尸体解剖发现生理盐水组均有腹腔转移，3例发生肺转移，游离卡铂组2例出现腹腔转移，未见肺转移，CBP-PLGA Ms组肿瘤局限于肝内，未见转移。