In bacteria, archaea, and lower eukaryotes, the unwinding process begins at a sequence called the replication origin, which contains several conserved binding sites for a protein called the initiator.

• 在细菌、原生生物和低等真核生物中，解链过程开始于一个被称作复制起点的序列，它包括几个蛋白质（起始子）保守结合位点。