In 1971, Folkman, a professor with Harvard University, put forward that the growth and metastasis of tumor were determined by the formation of blood vessels. Prevention of angiogenesis can inhibit the growth of tumors.

• 1971年 ,美国哈佛大学教授Folk man提出肿瘤的生长与转移都依赖于血管生成 ,阻止血管生成能抑制肿瘤生长。