Immunohistochemical analysis of human skin, nevi, and melanoma samples implicates loss of IGFBP7 expression as a critical step in melanoma genesis.

• 对于人体皮肤、痣和黑色素瘤样本免疫组织化学分析，均提示：IGFBP7表达的缺失为黑色素瘤形成的一个关键步骤。