If antigen present cells (APCs) provide MHC-peptides only, do not present costimulatory signals such as CD80 and CD86 to T lymphocytes at the same time, T lymphocytes will became anergy, immune tolerance will be induced.

• 如果抗原提呈细胞(antigen present cell，APC)只提供MHC-抗原肽复合物而不提供CD80、CD86等共刺激信号，将使淋巴细胞无能，诱导免疫耐受。