Human breast carcinoma cells transfected by E1A gene was remarkably more sensitive to Epirubicin and Taxotere,but not sensititive to 5-flourouracil and sensitivity was increased by 11 times and 15 times compared with that of MCF-7 and MCF-7-vect cells.

• 转染E1A基因的人乳腺癌细胞(MCF-7-E1A)对表阿霉素和泰素帝的敏感性显著增加,与MCF-7和MCF-7-vect细胞系比较,MCF-7-E1A细胞对表阿霉素和泰素帝的敏感性增加11倍和15倍; 对5-氟尿嘧啶的增敏作用不明显。