However, with the extensive inflammation characteristic of toxic megacolon the full thickness of the bowel wall may be involved, and the process may progress to necrosis and perforation of the colon.

• 然而，伴随中毒性巨结肠炎症扩大的特点，累及增厚全层肠壁，且进程将继续并坏死和穿透结肠。