However, because of the lack of global distribution data in higher eukaryotic systems, the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined.

• 然而，由于在高等真核生物系统中缺乏全局分布数据，组蛋白修饰的基因特异性组合模式的存在在某种程度上仍然有待确定。