However, an increased risk of hyperkalemia was reported when spironolactone was widely used.Close monitoring of serum potassium and renal function is thus required during such a therapy.

• 醛固酮受体拮抗剂的适应证为严重心力衰竭患者和心肌梗死后心力衰竭，使用时必须密切监测血钾和肌酐水平。